ML141

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML141 是 Rho 家族 GTPase cdc42 的有效、选择性和可逆非竞争性抑制剂，IC50 为 200 nM。

ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.

ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.

ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice. Animal Model:C57Bl/6J mice Dosage:10 μM Administration:Intracerebroventricular injection Result:Increased anxiety in mice.

CID2950007

Angiogenesis

CDK

cdc42

Cancer

——

71203-35-5

407.49

C22H21N3O3S

>98% (HPLC)

DMSO: 81 mg/mL warmed (198.77 mM)

O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O

4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years