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CDK4/6-IN-6
CAS No. 2380321-51-5
CDK4/6-IN-6 ( —— )
产品货号. M28244 CAS No. 2380321-51-5
CDK4/6-IN-6 是一种有效的 CDK4/CDK6 抑制剂，对于 CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值分别为 0.6 nM 和 13.9 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2001 | 有现货 |
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| 10MG | ￥3216 | 有现货 |
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| 25MG | ￥5370 | 有现货 |
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| 50MG | ￥7655 | 有现货 |
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| 100MG | ￥10368 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CDK4/6-IN-6
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CDK4/6-IN-6 是一种有效的 CDK4/CDK6 抑制剂，对于 CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值分别为 0.6 nM 和 13.9 nM。
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产品描述CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.(In Vitro):Using phosphorylated Rb S795 ELISA assay in JEKO-1 cells, CDK4/6-IN-6 has IC50s of 38.5 nM for CDK4/Cyclin D1 and 144.9 nM for CDK6/Cyclin D3, respectively .
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体外实验PF-07220060 (CDK4/6-IN-6; example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells.
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体内实验——
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同义词——
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通路Angiogenesis
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靶点CDK
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受体NR2B-NMDA
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研究领域——
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适应症——
化学信息
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CAS Number2380321-51-5
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分子量463.93
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分子式C22H27ClFN5O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (538.87 mM)
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SMILESCC(C)n1c2cc(-c(nc(N[C@H](CCOC3)[C@@H]3O)nc3)c3Cl)cc(F)c2nc1C(C)(C)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.
