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Bay K-8644
CAS No. 71145-03-4
Bay K-8644 ( Bay K8644 )
产品货号. M15726 CAS No. 71145-03-4
Bay K-8644 是一种有效的 L 型钙通道 (LTCC) 激活剂，EC50 为 17.3 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥398 | 有现货 |
|
| 5MG | ￥787 | 有现货 |
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| 10MG | ￥1264 | 有现货 |
|
| 25MG | ￥2474 | 有现货 |
|
| 50MG | ￥3655 | 有现货 |
|
| 100MG | ￥5157 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Bay K-8644
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Bay K-8644 是一种有效的 L 型钙通道 (LTCC) 激活剂，EC50 为 17.3 nM。
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产品描述Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo; enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts (MEFs) to induce pluripotent stem cells (iPSCs) combination with BIX-01294.
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体外实验In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.
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体内实验A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.
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同义词Bay K8644
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通路GPCR/G Protein
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靶点Calcium Channel
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受体L-type calcium channel
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研究领域Other Indications
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适应症——
化学信息
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CAS Number71145-03-4
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分子量356.3
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分子式C16H15F3N2O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (233.88 mM)
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SMILESO=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC
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化学全称1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.
2. Greenberg DA, et al. Brain Res. 1984 Jul 9;305(2):365-8.
3. Bourson A, et al. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.
产品手册
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