Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

具有镇痛、抗炎和解热作用的化合物。它是氨基比林的磺酸钠。

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable.

Cell Proliferation Assay Cell Line:PaTu 8988 t, Panc-1 Concentration: 1, 10, 100, 250, 500 μM Incubation Time:48 hours Result:Inhibited proliferation in the PaTu 8988 t cell line with 1–500 μM and with concentrations of 1 μM,10 μM, 100 μM, and 250 μM in the Panc-1 cell line.Increased the apoptosis rate after 9 h.

Animal Model:Male Wistar rats (270-300 g), with peripheral neuropathic painDosage:500 mg/kg Administration:Intraperitoneal injection, twice a day, for 7 days Result:Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.Animal Model:Pain model in rats Dosage:250 or 500 mg/kg Administration: p.o.Result:Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression.Reduced MDA levels in the carrageenan paw test and increased tGSH levels.

Dipyrone

Chromatin/Epigenetic

COX

COX-1

Inflammation/Immunology

——

68-89-3

333.34

C13H16N3NaO4S

>98% (HPLC)

DMSO: 10 mM

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)([O-])=O.[Na+]

Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt

(-20℃)

With Ice Pack

≥ 2 years