Norethindrone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

炔诺酮是一种合成孕激素，模仿内源性卵巢激素孕酮的作用。

Norethindrone is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.(In Vitro):Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.

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Norethisterone | NSC 9564

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

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68-22-4

298.42

C20H26O2

>98% (HPLC)

Ethanol: 5 mg/mL (16.75 mM); DMSO: 60 mg/mL (201.05 mM)

C[C@]12CC[C@H]3[C@@H](CCC4=CC(CC[C@H]34)=O)[C@@H]1CC[C@@]2(O)C#C

(8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

(-20℃)

With Ice Pack

≥ 2 years