LH-846

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LH846 是 CK1δ 的选择性抑制剂（CK1δ、ε 和 α 的 IC50 值为 290 nM、1.3 uM 和 2.5 uM）；对 CK2 没有表现出抑制活性。

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells.

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LH846 | LH-846 | LH 846

Metabolic Enzyme/Protease

Casein Kinase

CK1

Cancer

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639052-78-1

316.81

C16H13ClN2OS

>98% (HPLC)

DMSO: 45 mg/mL

O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3

N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide

(-20℃)

With Ice Pack

≥ 2 years