Wogonin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

汉黄芩素是一种天然存在的单黄酮类化合物，可以抑制CDK8和Wnt的活性，并具有抗炎和抗肿瘤作用。

Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.(In Vitro):Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 μM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.(In Vivo):Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.

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BRN 0287152

Others

Other Targets

Others

Inflammation/Immunology

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632-85-9

284.26

C16H12O5

>98% (HPLC)

DMSO: 10 mM

O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

(-20℃)

With Ice Pack

≥ 2 years