IMR-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IMR-1是一类新型Notch抑制剂，针对转录激活，IC50为6 μMol/L。

IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.

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Animal Model:Nude mouses with adenocarcinoma xenograft.Dosage:15mg/kg Administration:I.p.; for 28 days Result:Blocks tumor establishment.

IMR-1 | IMR 1 | IMR1. Inhibitor of Mastermind Recruitment-1

Others

Other Targets

Notch

Cancer

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310456-65-6

353.41

C15H15NO5S2

>98% (HPLC)

DMSO : ≥ 100 mg/mL 282.96 mM; H2O : < 0.1 mg/mL

C(=O)(COc1c(cc(cc1)/C=C/1\SC(=S)NC1=O)OC)OCC

(E)-Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate

(-20℃)

With Ice Pack

≥ 2 years