BYK191023

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BYK191023 (BYK-191023) 是一种有效的、高选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC50 为 86 nM。

BYK191023 (BYK-191023) is a potent, highly selective inhibitor of inducible nitric-oxide synthase (iNOS) with IC50 of 86 nM, >20-fold selectivity over nNOS and eNOS (IC50=17 and 162 uM); exhibits an affinity for iNOS, nNOS, and eNOS of 450 nM, 30 uM, and >500 uM, respectively; inhibits cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells with IC50 values 40- to 100-fold higher than at the isolated enzyme; dose-dependently suppresses the LPS-induced increase in plasma nitrate/nitrite (NO(x)) levels with ED50 of 14.9 micromol/kg/h, partially restores normal blood pressure responses to norepinephrine and sodium nitroprusside in model of LPS-induced vascular hyporesponsiveness.

——

——

BYK-191023

Immunology/Inflammation

NOS

NOS

——

——

608880-48-4

254.293

C14H14N4O

>98% (HPLC)

——

COC1=CC(=NC=C1)CCC2=NC3=C(N2)C=CC=N3

2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine

(-20℃)

With Ice Pack

≥ 2 years