Sasapyrine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Salsalate 是一种口服非甾体类抗炎药。水杨酸作为抗炎和抗风湿剂的作用方式可能是由于抑制前列腺素的合成和释放。

Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.

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Disalcid | Nobacid | NSC 49171 | Salflex | Salina | Sasapirin

Chromatin/Epigenetic

COX

COX-1| COX-2

Inflammation/Immunology

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552-94-3

258.23

C14H10O5

>98% (HPLC)

Ethanol: 52 mg/mL (201.37 mM); DMSO: 52 mg/mL (201.37 mM)

C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O

2-(2-hydroxybenzoyl)oxybenzoic acid

(-20℃)

With Ice Pack

≥ 2 years