Etonogestrel

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Etonogestrel (3-Oxodesogestrel) 是孕激素去氧孕烯的生物活性代谢物，Etonogestrel 与靶器官中的孕酮受体 (progesterone receptor) 和雌激素受体 (estrogen receptors) 高亲和力地结合。Etonogestrel 诱导 FKBP51 mRNA 和蛋白表达。

Etonogestrel is a steroidal progestin used in hormonal contraceptives.(In Vitro):Etonogestrel inhibits fertility by inhibiting the release of luteinizing hormone (LH), one of the reproductive hormones important in ovulation.Etonogestrel also increases the viscosity of cervical mucus, which hinders the passage of spermatozoa and alters the lining of the uterus to prevent implantation of a fertilized egg into the endometrium.Etonogestrel, a progestin, is a substrate of the CYP 3A4 oxidase system.Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).

Etonogestrel inhibits fertility by inhibiting the release of luteinizing hormone (LH), one of the reproductive hormones important in ovulation.Etonogestrel also increases the viscosity of cervical mucus, which hinders the passage of spermatozoa and alters the lining of the uterus to prevent implantation of a fertilized egg into the endometrium.Etonogestrel, a progestin, is a substrate of the CYP 3A4 oxidase system.Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs). Western Blot AnalysisCell Line:Human endometrial stromal cells (HESCs) Concentration:100 nM Incubation Time:24 hoursResult:Increased FKBP51 mRNA and protein levels.

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ORG 3236 | 3-keto Desogestrel | 3-oxo Desogestrel

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

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54048-10-1

324.46

C22H28O2

>98% (HPLC)

DMSO: 10 mM

CC[C@]12CC(=C)[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

(-20℃)

With Ice Pack

≥ 2 years