IRAK-1-4 Inhibitor I

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IRAK-1-4 Inhibitor I 是一种有效的 IRAK4 和 IRAK1 双重抑制剂，IC50 分别为 0.2 uM 和 0.3 uM。

IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively; displays IC50 of >10 uM against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC; eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8 in human intestinal epithelial cells.

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IRAK-1/4 Inhibitor I

Immunology/Inflammation

IRAK

IRAK-1|IRAK-4

Inflammation/Immunology

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509093-47-4

395.4

C20H21N5O4

>98% (HPLC)

10 mM in DMSO

O=C(NC1=NC2=CC=CC=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4

Benzamide, N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-

(-20℃)

With Ice Pack

≥ 2 years