Estradiol benzoate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Estradiol Benzate 是一种雌二醇类似物，可与人、鼠和鸡 ERα 结合，IC50 为 22-28 nM。

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

Cell Cytotoxicity Assay Cell Line:HFFs Concentration:0-500 μM Incubation Time:72 h Result:Inhibited HFFs at the 50% toxicity of 34.11 μM.

Animal Model:Ovx miceDosage:20, 100 or 200 μg/kg Administration:Subcutaneous injection (s.c.)Result:Significantly reversed the lowered uterine weight induced by Ovx.Had no obvious effects on locomotor activity in Ovx mice.Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx.Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).

β-Estradiol Benzoate | 17β-Estradiol 3-Benzoate | 17β-Oestradiol Benzoate | E2 Benzoate

Endocrinology/Hormones

Estrogen Receptor/ERR

mERα| hERα

Endocrinology

——

50-50-0

376.49

C25H28O3

>98% (HPLC)

DMSO: 75 mg/mL (199.2 mM)

O=C(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1)C5=CC=CC=C5

[(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate

(-20℃)

With Ice Pack

≥ 2 years