R-1479

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

R-1479 (4'-Azidocytidine) 是一种核苷类似物，是特异性的 HCV RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。R-1479 在 HCV 亚基因组复制体系中抑制 HCV 复制，IC50 为 1.28 μM。

A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay); shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at >2 mM; inhibits RNA synthesis mediated by NS5B with IC50 of 320 nM, is the active form of Balapiravir (R-1479).

R-1479 (R1479) inhibits HCV RNA replication with a mean IC50 value of 1.28 μM when measured as dose-dependent reduction of Renillaluciferase activity after a 72 h incubation of proliferating replicon cells. R-1479 shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM. The most potent and non-cytotoxic derivative is R-1479 with an IC50 of 1.28 μM in the HCV replicon system. The triphosphate of R-1479 is prepared and shown to be an inhibitor of RNA synthesis mediated by NS5B (IC50=320 nM), the RNA polymerase encoded by HCV. R-1479 displays good activity in the replicon assay with no measurable cytotoxic or cytostatic effect.

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R 1479 | 4'-Azidocytidine | R1479

Microbiology/Virology

HCV

HCV

Infection

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478182-28-4

284.2288

C9H12N6O5

>98% (HPLC)

DMSO

NC1=NC(N([C@@H]2O[C@@](N=[N+]=[N-])([C@H]([C@H]2O)O)CO)C=C1)=O

Cytidine, 4'-C-azido-

(-20℃)

With Ice Pack

≥ 2 years