Skp2-IN-C1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Skp2-IN-C1 是 Skp2 介导的 p27 降解的特异性小分子抑制剂。

Skp2-IN-C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases.

Skp2 Inhibitor C1 (10-50 μM; 12 hr) decreases the viability of THP-1, U266 and RPMI 8226 cells.Skp2 Inhibitor C1 (25 μM) increases p27 protein levels in U266 and RPMI 8226 cells by inhibiting ubiquitination.Skp2 Inhibitor C1 (25 μM) inhibits cell cycle of U266 and RPMI 8226 cells. Cell Cycle Analysis Cell Line:B lymphocytes, THP-1, U266 and RPMI 8226 cells Concentration:0, 5, 10, 25, and 50 μM Incubation Time:12 hr, 24 hr, 36 hr, and 48 hr Result:Significantly decreased the viability of U266 and RPMI 8226 cells at 10 μM for 12 hours.Decreased THP-1 cell viability at 50 μM for 12 hours.Cell Viability Assay Cell Line:U266 and RPMI 8226 cells Concentration:0, 5, 10, 25, and 50 μM Incubation Time:12 hr Result:Increased the percentages of U266 and RPMI 8226 cells in the G0/G1 phase, while decreased the percentages in S and G2/M phases.

Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg; 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT).

MDK-1699 | MDK 1699 | MDK1699 | Skp2 inhibitor C1 and SKPin C1.

Proteasome/Ubiquitin

E3 Ubiquitin Ligase

Skp2

Cancer

——

432001-69-9

465.336

C18H13BrN2O4S2

>98% (HPLC)

DMSO : 6.4 mg/mL 13.75 mM

O=C(O)COC1=CC=C(Br)C=C1/C=C(SC(N2CC3=CC=CN=C3)=S)/C2=O

(Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

(-20℃)

With Ice Pack

≥ 2 years