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HS-152
CAS No. ——
HS-152 ( HS152 | HS 152 )
产品货号. M17010 CAS No. ——
HS-152 (HS152) 是 SMAD 泛素调节因子 1 (SMURF1) 的特异性小分子抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HS-152
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述HS-152 (HS152) 是 SMAD 泛素调节因子 1 (SMURF1) 的特异性小分子抑制剂。
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产品描述HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively); inhibits both SMURF1 and SMURF2 catalytic activities, effectively inhibits protrusive activity in HEK293T cells and blocks TGFβ-induced epithelial-mesenchymal transition (EMT) in MDCK cells, similar to the effects on these processes caused by SMURF1 loss.
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体外实验——
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体内实验——
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同义词HS152 | HS 152
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通路Proteasome/Ubiquitin
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靶点E3 Ubiquitin Ligase
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受体E3 Ubiquitin Ligase
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量400.863
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分子式C20H21ClN4O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC(NC1=CC=CC(C(N2CCN(C)CC2)=O)=C1)=O)C3=CC=C(Cl)C=C3
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化学全称4-chloro-N-((3-(4-methylpiperazine-1-carbonyl) phenyl) carbamoyl)-benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. J Biol Chem. 2018 Dec 26. pii: jbc.RA118.003822. doi: 10.1074/jbc.RA118.003822.
