Telaprevir

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效、选择性、共价、口服生物可利用的 HCV NS3/4A 蛋白酶抑制剂，Ki 为 7 nM。

A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.HCV Infection Approved.

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VX-950 | VX950 | VX 950

Microbiology/Virology

HCV

HCVNS3-4Aserineprotease

Infection

HCV Infection

402957-28-2

679.8493

C36H53N7O6

>98% (HPLC)

10 mM in DMSO

O=C([C@@H]1[C@](CCC2)([H])[C@]2([H])CN1C([C@@H](NC([C@H](C3CCCCC3)NC(C4=NC=CN=C4)=O)=O)C(C)(C)C)=O)N[C@@H](CCC)C(C(NC5CC5)=O)=O

Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-

(-20℃)

With Ice Pack

≥ 2 years