Penciclovir

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种鸟苷类似物抗病毒剂，用于治疗各种疱疹病毒 (HSV) 感染。

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.HSV Infection Approved(In Vitro):Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells.(In Vivo):Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse.

Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells. Cell Cytotoxicity AssayCell Line:MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells Concentration:0-100 μg/ml Incubation Time:Result:Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.

Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse. Animal Model:Three-week-old female Balb/c mice Dosage:100 mg/kg Administration:S.c.; daily for 5 days Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.

VSA-671 | BRL-39123

Microbiology/Virology

HSV

EBV|HCMV|HSV-1|HSV-2|VZV

Infection

HSV Infection

39809-25-1

253.2578

C10H15N5O3

>98% (HPLC)

DMSO: ≥ 53 mg/mL

C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N

6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-

(-20℃)

With Ice Pack

≥ 2 years