AZ 3146 ( AZ3146 | AZ 3146 | AZ-3146 )

产品货号. M17147 CAS No. 1124329-14-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AZ 3146
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AZ3146 是一种选择性 Mps1 抑制剂，IC50 约为 35 nM。
产品描述

AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.
体外实验

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体内实验

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同义词

AZ3146 | AZ 3146 | AZ-3146
通路

Microbiology/Virology
靶点

HSV
受体

Mps1
研究领域

Cancer
适应症

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CAS Number

1124329-14-1
分子量

452.55
分子式

C24H32N6O3
纯度

>98% (HPLC)
溶解度

DMSO : 11.75 mg/mL 25.96 mM;
SMILES

COc1c(Nc2ncc3n(C)c(=O)n(C4CCCC4)c3n2)ccc(OC2CCN(C)CC2)c1
化学全称

9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

1. Hewitt L, et al. J Cell Biol, 2010, 190(1), 25-34.

计算器

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