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首页- Products - Membrane Transporter/Ion Channel - Beta Amyloid - Homotaurine

Homotaurine

CAS No. 3687-18-1

Homotaurine ( Homotaurine | NC 531 | NC 758 | NSC 77071 | 3-Sulfopropylamine )

产品货号. M14268 CAS No. 3687-18-1

由于其结构与神经递质 γ-氨基丁酸 (GABA) 相似，因此具有 GABA 作用，可用作抗惊厥药。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG 获取报价 有现货
1G ￥285 有现货
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生物学信息

  • 产品名称
    Homotaurine
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    由于其结构与神经递质 γ-氨基丁酸 (GABA) 相似，因此具有 GABA 作用，可用作抗惊厥药。
  • 产品描述
    Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.(In Vitro):Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.(In Vivo):Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery.
  • 体外实验
    Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.
  • 体内实验
    Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery. Animal Model:Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO) Dosage:50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg Administration:Intraperitoneal injection; once Result:Dose-dependently reduced the infarct volume after MCAO.
  • 同义词
    Homotaurine | NC 531 | NC 758 | NSC 77071 | 3-Sulfopropylamine
  • 通路
    Membrane Transporter/Ion Channel
  • 靶点
    Beta Amyloid
  • 受体
    Aβ| GABA
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    3687-18-1
  • 分子量
    139.17
  • 分子式
    C3H9NO3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    O=S(CCCN)(O)=O
  • 化学全称
    3-aminopropane-1-sulfonic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Fariello RG, et al. Neurology, 1982, 32 (3): 241–5.
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