Secnidazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Secnidazole (RP-14539) 是一种唑类抗生素和黏质沙雷菌毒力的咪唑缓释剂，具有口服活性。Secnidazole 作为一种类似于酰基高丝氨酸内酯，能有效抑制 QS 导致铜绿假单胞菌的发病衰减。Secnidazole 在体外对多种厌氧革兰氏阴性和革兰氏阳性细菌均有抗菌活性。

Secnidazole (trade names Flagentyl, Sindose, Secnil) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. (In Vitro):Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively.Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition.Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2.Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL.(In Vivo):Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice.

Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively.Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition. Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2.Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL. Cell Viability Assay Cell Line:S.marcescens Concentration:10 μL (the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL)Incubation Time:20 hResult:Had no inhibitory effect on S.marcescens growth at 2 mg/mL (equivalent to 1/5 MIC).

Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice. Animal Model:Female healthy albino mice Dosage:100 μL Administration:100 μL; ip.; for 5 days Result:Significantly diminished the bacteria s capacity to kill mice.

PM 185184 | RP 14539

Others

Other Targets

Others

Infection

——

3366-95-8

185.18

C7H11N3O3

>98% (HPLC)

Ethanol: 37 mg/mL (199.8 mM); Water: 37 mg/mL (199.8 mM); DMSO: 37 mg/mL (199.8 mM)

(2RS)-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol

1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol

(-20℃)

With Ice Pack

≥ 2 years