Succimer

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Succimer 是一种铅螯合剂。琥珀酸的作用机制是作为铅螯合活性。

Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.(In Vivo):Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.

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Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.

Succimer | DMSA

Others

Other Targets

Cadmium| Lead| Mercury| Others

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304-55-2

182.22

C4H6O4S2

>98% (HPLC)

DMSO: 10 mM

O=C(O)[C@@H](S)[C@@H](S)C(O)=O

meso-2,3-Dimercaptosuccinic acid;

(-20℃)

With Ice Pack

≥ 2 years