SB-3CT

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB-3CT 是一种有效的选择性明胶酶抑制剂，对 MMP-2 和 MMP-9 的 Ki 值分别为 13.9 nM 和 600 nM。

SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant Ki of 400±15 nM. Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity.

SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice. Animal Model:Five-week-old male C.B.-17.SCID mice Dosage:50 mg/kg Administration:IP; every other day; five weeks Result:Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.

Matrix Metalloproteinase-2/9 Inhibitor IV | MMP-2/MMP-9 Inhibitor IV

Metabolic Enzyme/Protease

MMP

MMP-2| MMP-9

Cancer

——

292605-14-2

306.4

C15H14O3S2

>98% (HPLC)

Ethanol: 10 mg/mL warmed (32.63 mM); DMSO: 61 mg/mL (199.08 mM)

O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O

2-(((4-phenoxyphenyl)sulfonyl)methyl)thiirane

(-20℃)

With Ice Pack

≥ 2 years