Daun02

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Daun02 是一种前药，可被 β-半乳糖苷酶转化为柔红霉素，使表达 β-半乳糖苷酶和 Fos 的激活神经元失活。

Daun02 a prodrug that is converted by β-galactosidase to Daunorubicin, inactivate activated neurons that express both β-galactosidase and Fos, specifically attenuates cocaine-induced locomotor activity, also attenuates cocaine-induced β-galactosidase expression; daunorubicin, the active product of Daun02 metabolism by β-galactosidase, decreases the activity of MSNs in rat brain slices and that Daun02 strongly decreases the excitability of rat MSN primary cultures expressing β-galactosidase upon D1 dopamine receptor stimulation; Daun02-inactivation method, selectively inactivate only those neurons activated by cocaine in an environment repeatedly paired with drug injections.

Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca2+)-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively.

Daun02 is a good substrate for β-gal with Km and Vmax values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin.

Daun 02 | Daun-02

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

ADC Cytotoxin

Cancer

——

290304-24-4

884.7895

C41H44N2O20

>98% (HPLC)

10 mM in DMSO

O=C(OCC1=CC=C(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)C([N+]([O-])=O)=C1)N[C@@H]3[C@H](O)[C@H](C)O[C@@H](OC4CC(O)(C(C)=O)CC5=C(O)C6=C(C(C7=C(OC)C=CC=C7C6=O)=O)C(O)=C45)C3

(1R,2R,6S,18R,20S)-3-nitro-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)benzyl (2S,3S,4S,6R)-6-(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-2H

(-20℃)

With Ice Pack

≥ 2 years