Mertansine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mertansine (DM1) 是一种微管蛋白抑制剂；含有硫醇的美登木素生物碱，可形成抗体-药物偶联物 (ADC)。

Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.(In Vitro):Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines.Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX.(In Vivo):Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg.

Cell Proliferation Assay Cell Line:Malignant B16F10 melanoma cells Concentration:0, 0.01, 0.1, and 1 μg/mL Incubation Time:4 h Result:Showed antitumor activity in malignant B16F10 melanoma cells, with an IC50 of 0.092 μg/mL. Co-delivery of DTX and DM1, both of which inhibit tumor cell growth by inhibiting mitosis, is an effective strategy to achieve a combinatorial anticancer effect.

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DM1 | Maytansinoid DM1 | DM-1 | Maytansinoid DM-1

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

Others

Cancer

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139504-50-0

738.2877

C35H48ClN3O10S

>98% (HPLC)

DMSO: ≥ 83.33 mg/mL

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C\C=C(\CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@H]([C@]4(C1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)/C)OC)(NC(=O)O2)O

Maytansine, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-

(-20℃)

With Ice Pack

≥ 2 years