Naproxen sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Naproxen 是 COX-1 和 COX-2 的 COX 抑制剂，IC50 分别为 8.7 μM 和 5.2 μM。

Naproxen is a?COX?inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.(In Vitro):Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.(In Vivo):Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).

Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.

Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).

Naproxen sodium | RS 3650 | Sodium naproxen | Naproxen natrium

Chromatin/Epigenetic

COX

COX-1| COX-2

Inflammation/Immunology

——

26159-34-2

252.24

C14H13NaO3

>98% (HPLC)

Water: 50 mg/mL (198.22 mM); DMSO: 3 mg/mL (11.89 mM)

O=C([O-])[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1.[Na+]

2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-

(-20℃)

With Ice Pack

≥ 2 years