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Tolnaftate
CAS No. 2398-96-1
Tolnaftate ( NSC 233648 | SCH 10144 )
产品货号. M13694 CAS No. 2398-96-1
托萘酯是一种合成硫代氨基甲酸盐，用作抗真菌剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥132 | 有现货 |
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| 1G | ￥213 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥185 | 有现货 |
|
生物学信息
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产品名称Tolnaftate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述托萘酯是一种合成硫代氨基甲酸盐，用作抗真菌剂。
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产品描述Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.(In Vitro):Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
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体外实验Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.
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体内实验——
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同义词NSC 233648 | SCH 10144
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通路GPCR/G Protein
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靶点Hedgehog (Hh)
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受体Smoothened
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研究领域Infection
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适应症——
化学信息
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CAS Number2398-96-1
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分子量307.42
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分子式C19H17NOS
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纯度>98% (HPLC)
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溶解度DMSO: 62 mg/mL (201.68 mM)
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SMILESS=C(OC1=CC=C2C=CC=CC2=C1)N(C)C3=CC=CC(C)=C3
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化学全称O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Barrett-Bee K, Dixon G. Acta Biochim Pol. 1995;42(4):465-79.
