CCT-367766

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CCT-367766 (CCT367766) 是一种新型异双功能 PROTAC，可结合并降解细胞中假定的转录因子调节因子 Pirin。

CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.

CCT367766 (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a?the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells.CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells.CCT367766 (0.5-50 nM; 2 hours) dose-dependently rescuses pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.Western Blot AnalysisCell Line:SK-OV-3 human ovarian cancer cells Concentration:50, 150, 250, 500 and 1500 nMIncubation Time:2 hours, 4 hours, 24 hours Result:Decreased pirin protein expression.Western Blot Analysis Cell Line:SK-OV-3 human ovarian cancer cells Concentration:0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 nM Incubation Time:2 hours Result:Completely degraded pirin just at50 nM treatment.

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CCT367766 | CCT 367766

PROTACs

PROTAC

PROTAC

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2229856-58-8

946.41

C49H48ClN7O11

>98% (HPLC)

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O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C9OCCOC9=C8)=O)=CC=C7Cl

N-(2-Chloro-5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)phenyl)-2-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)quinoline-6-carboxamide

(-20℃)

With Ice Pack

≥ 2 years