QCA570

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

QCA570 是一种新型、高效的 BET 降解剂 (PROTAC)；在 pM 水平有效诱导 BET 蛋白降解并抑制人急性白血病细胞系的细胞生长。

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level; inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively; causes complete and durable tumor regression in leukemia xenograft models in mice.

QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date.

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QCA 570 | QCA-570

PROTACs

PROTAC

PROTAC

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2207569-08-0

695.798

C39H33N7O4S

>98% (HPLC)

In Vitro:?DMSO : 40 mg/mL (57.49 mM)

O=C(C(N(CC1=C2C=CC=C1C#CCCCN3N=CC(C#CC(S4)=C(CC5=CC=CC=C5)C6=C4N7C(COC6)=NN=C7C)=C3)C2=O)CC8)NC8=O

3-(4-(5-(4-((3-Benzyl-9-methyl-4H,6H-thieno[2,3-e][1,2,4]-triazolo[3,4-c][1,4]oxazepin-2-yl)ethynyl)-1H-pyrazol-1-yl)pent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

(-20℃)

With Ice Pack

≥ 2 years