Baloxavir Marboxil ( S-033188 | Xofluza )

产品货号. M13102 CAS No. 1985606-14-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Baloxavir Marboxil
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Baloxavir Marboxil (S-033188, Xofluza) 是 Baloxavir Acid (S-033447) 的前药，可有效、选择性地抑制甲型和乙型流感病毒聚合酶 PA 亚基内的帽子依赖性核酸内切酶。
产品描述

Baloxavir Marboxil (S-033188, Xofluza) is the prodrug of Baloxavir acid (S-033447) that potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses. Influenza Approved(In Vitro):Baloxavir marboxil is a polymerase acidic protein (PA) endonuclease inhibitor.
体外实验

Baloxavir marboxil is a polymerase acidic protein (PA) endonuclease inhibitor.
体内实验

——
同义词

S-033188 | Xofluza
通路

Microbiology/Virology
靶点

Influenza Virus
受体

Influenza Virus
研究领域

Infection
适应症

Influenza

CAS Number

1985606-14-1
分子量

571.552
分子式

C27H23F2N3O7S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 50 mg/mL 87.48 mM
SMILES

O=C(OCOC(C(C=C1)=O)=C(N1N([C@@H]2C3=CC=CC=C3SCC4=C(F)C(F)=CC=C24)[C@@]5([H])N6CCOC5)C6=O)OC
化学全称

({(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate

1. Omoto S, et al. Sci Rep. 2018 Jun 25;8(1):9633.

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