Loxapine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种典型的抗精神病化合物，对多巴胺 D4 和血清素 5-HT2 受体具有极强的结合亲和力。

A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.Schizophrenia Approved.

In the presence of Loxapine, [3H]ketanserin binds to 5-HT2 receptor in Frontal cortex of brain in human and bovine with Ki value of 6.2 nM and 6.6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5-HT2≥D4>>>D1>D2 in comparing competition experiments involving the human membranes.Loxapine (0-20 μM, 24 h or 72 h) reduces IL-1β secretion by LPS-activated mixed glia cultures, reduces IL-2 secretion in mixed glia cultures, and decreases IL-1β and IL-2 secretion in LPS-induced microglia cultures.

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Adasuve | AZ-004 | CL 62,362 | Cloxazepine | Dibenzacepin | Dibenzoazepine | HF 3170 | HF3170

GPCR/G Protein

5-HT Receptor

5-HT Receptor

Neurological Disease

Schizophrenia

1977-10-2

327.808

C18H18ClN3O

>98% (HPLC)

10 mM in DMSO

CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1

Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

(-20℃)

With Ice Pack

≥ 2 years