Spiroxatrine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Spiroxatrine (R 5188) 是一种选择性的 5-HT1α 和 α-肾上腺素能 (α2-adrenergic) 双拮抗剂，对5-HT1α、5-HT1 β 和 5-HT2 的 Ki 值分别为 3.94、224000、118.5nM。Spiroxatrine (R 5188) 有镇静作用。

Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.

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Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model Dosage:1, 10, 25 ug, 5 days Administration:Intraperitoneal injection (i.p.)Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats Dosage:4 mg/kg/day, 5 mins Administration:Intraperitoneal injection (i.p.)Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor | Dopamine Receptor | Adrenergic Receptor

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1054-88-2

379.45

C22H25N3O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 1.92 mg/mL (5.06 mM; 超声助溶 (<60°C)

O=C1C2(N(CN1)C3=CC=CC=C3)CCN(CC4OC=5C(OC4)=CC=CC5)CC2

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(-20℃)

With Ice Pack

≥ 2 years