Aminoguanidine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aminoguanidine Hydrochloride 是一种二胺氧化酶和 NO 合酶抑制剂。

Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.

Apoptosis Analysis Cell Line:A549Concentration:100-1000 μM Incubation Time:24 h Result:Showed protective effect on DOX-induced DNA damage and decreased DOX-induced apoptosis.Cell Proliferation Assay Cell Line:AR42J Concentration:100 μM Incubation Time:24-96 h Result:Showed a significant increase in cell proliferation after incubation for 48 h.

Animal Model:Male Swiss albino miceDosage:50 mg/kg Administration:Intraperitoneally 30 min before the administration of CCl4 Result:Inhibited the serum AST level and protected hepatotoxin-induced lipid peroxidation.Animal Model:Adult male Wistar ratsDosage:200 mg/kg Administration:Intraperitoneally 1 hour before the administration of CP and killed 16 hours after CP injection.Result:Attenuated CP-induced MDA elevation and prevented CP-induced protein oxidation.Restored the GSH levels and attenuated CP-induced increase in MPO activity.

Aminoguanidinium chloride | GER 11 | Pimagedine

Immunology/Inflammation

NOS

iNOS

Endocrinology

——

1937-19-5

110.55

CH6N4·HCl

>98% (HPLC)

DMSO: 10 mM

Cl.NN=C(N)N

——

(-20℃)

With Ice Pack

≥ 2 years