Jaceosidin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Jaceosidin (4'-Demethyleupatilin, Jaseocidin) 是一种三羟基黄酮，具有抗过敏、抗炎和诱导细胞凋亡的活性。

Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties; promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells; shows selective suppression of proliferation (IC50 = 82.1?μM in HSC-3 cells and 97.5?μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.

Cell Viability Assay Cell Line:Hec1A, KLE, HES and HESC cells Concentration:3.125, 6.25, 12.5, 25, 50, and 100 μM Incubation Time:48 hour Result:Showed cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM).

Animal Model:5-week-old male BALB/c mice (23-26 g) Dosage:10 and 20 mg/kg Administration:P.O. once a day for 3 days Result:Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.Animal Model:Male Sprague-Dawley rats (180-200 g)Dosage:20 mg/kg Administration:P.O., for 2 hour Result:Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.

4'-Demethyleupatilin | Jaseocidin

Natural Products

Flavonoids

UGT

Other Indications

——

18085-97-7

330.292

C17H14O7

>98% (HPLC)

DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13

5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one

(-20℃)

With Ice Pack

≥ 2 years