TA-01

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

酪蛋白激酶 CK1ε、CK1δ 和 p38α 的有效抑制剂，IC50 分别为 6.4、6.8 和 6.7 nM。

A potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively; inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.

TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.

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TA01 | TA 01

Metabolic Enzyme/Protease

Casein Kinase

CKIδ|CKI?|p38MAPkinase

Other Indications

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1784751-18-3

351.3246

C20H12F3N3

>98% (HPLC)

10 mM in DMSO

FC1=CC=CC=C1C2=C(C3=CC=NC=C3)NC(C4=C(F)C=CC=C4F)=N2

Pyridine, 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-

(-20℃)

With Ice Pack

≥ 2 years