SC-236

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SC-236 (SC58236) 是一种有效的、选择性的、口服活性的 COX-2 抑制剂，IC50 为 10 nM。

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM; displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM); exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.

Western Blot Analysis Cell Line:vECs.Concentration:15 μM Incubation Time:30 min.Result:Showd significant reduction in COX-2 level and increase in IκBα level, thus preventing ALSS-induced NFκB activation and inflammation in vECs.Western Blot Analysis Cell Line:COS 7 cells.Concentration:3 and 10 μM.Incubation Time:18 h (combined with 15d-PGJ2).Result:Acted in a concentration-dependent manner as a PPARγ agonist.

Animal Model:Seventy-six male adult Wistar rats weighing 200-220 g (CCl4-treated).Dosage:6 mg/kg.Administration:Orally, 3 times per week.Result:A marked induction of COX-2 protein expression was detected by immunohistochemistry in the liver of CCl4-treated rats.Significantly reduced the degree of liver fibrosis.Dramatically suppressed α-SMA expression in CCl4-treated rats.

SC236 | SC58236

Chromatin/Epigenetic

COX

COX

——

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170569-86-5

401.8

C16H11ClF3N3O2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (248.89 mM)

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O

4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years