Remodelin hydrobromide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

乙酰转移酶蛋白 NAT10 的有效抑制剂，可乙酰化组蛋白和微管。

A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules; significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells; does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.

Cell Proliferation Assay Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145 Concentration:0,10,20,40 μM Incubation Time:1,2,7 days Result:Inhibited NAT10 and suppressed the growth of both AR-positive and AR-negative prostate cancer cells. Displayed significantly decreased cell proliferation activity over time, compared to the control group.Decreased colony formation ability with a dose-dependent manner. Immunofluorescence Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145 Concentration:20 μM Incubation Time:24 h Result:Showed a significant decrease in both the positive labeling rate and the fluorescence intensity compared to the control group. Significantly reduced both the staining foci of IdU and the staining foci of CldU compared to control group. Western Blot Analysis Cell Line:Skin fibroblasts from LmnaG609G/G609G and wildtype (WT) littermates Concentration:1 μM Incubation Time:7 days Result:Decreased the higher level of the DNA double-strand break (DSB) marker gamma H2AX (γH2AX, Ser-139 phosphorylated histone H2AX).

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Remodelin HBr | Remodelin Hydrobromide

Cell Cycle/DNA Damage

HDAC

acetyl-transferaseNAT10

Other Indications

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1622921-15-6

363.2754

C15H15BrN4S

>98% (HPLC)

DMSO: ≥ 44 mg/mL

N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)

(-20℃)

With Ice Pack

≥ 2 years