SW-100

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SW-100 (SW100) 是一种有效的、选择性的、脑可渗透的 HDAC6 抑制剂，IC50 为 2.3 nM。

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms; selectively inhibits HDAC6-CD2 and enhances α-tubulin acetylation in cells with no effect on histone acetylation and selectively restores the impaired acetylated α-tubulin levels in the hippocampus of Fmr1-/- mice; ameliorates several memory and learning impairments in Fmr1-/- mice, thus modeling the intellectual deficiencies associated with Fragile X syndrome (FXS).

SW-100 (0.01-10 μM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner. Western Blot Analysis Cell Line:HEK293 cells Concentration:0.01, 0.1, 1, 10 μM Incubation Time:48 hours Result:Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome. Animal Model:8-10 weeks old C57BL/6 mice (Fmr1-/- mice) Dosage:20 mg/kg Administration:Intraperitoneal injection; twice a day for two days Result:Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1-/- mice。

SW100 | SW 100

Cell Cycle/DNA Damage

HDAC

HDAC

——

——

2126744-35-0

316.785

C17H17ClN2O2

>98% (HPLC)

DMSO : ≥ 125 mg/mL 394.60 mM

C1CC2=C(C=CC(=C2)Cl)N(C1)CC3=CC=C(C=C3)C(=O)NO

4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide

(-20℃)

With Ice Pack

≥ 2 years