SCH-58261

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SCH-58261 是一种有效、选择性、竞争性 A2A 腺苷受体拮抗剂，在大鼠和牛脑中的 Ki 值分别为 2.3 nM 和 2.0 nM。

SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively; displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively; reverses reperfusion injury (IR) increased hippocampal Glu, GABA, glycine and aspartate, MPO, TNF-α, nitric oxide, and PGE in Male Wistar rats.

Cell Viability Assay Cell Line:H1975 cells Concentration:10 nM-10 μM Incubation Time:7 days Result:Produced a concentration-dependent decrease in H1975 cell growth.Cell Proliferation Assay Cell Line:CAF cells Concentration:25 μM Incubation Time:72 hours Result:Inhibit the growth of CAF1 and CAF2 cells.

Animal Model: 4?6 weeks old athymic nude mice (NCI) with PC9 cells xenograftDosage:2 mg/kg Administration:Intraperitoneal injection; daily; for 20 days Result:Decreased tumor growth.

SCH 58261 | SCH58261

Apoptosis

Adenosine Receptor

A2A(bovine)|A2A(rat)

Cancer

——

160098-96-4

345.358

C18H15N7O

>98% (HPLC)

DMSO: ≥ 34 mg/mL

NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14

7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-

(-20℃)

With Ice Pack

≥ 2 years