SG3199 ( SG-3199 | SG 3199 )

产品货号. M12278 CAS No. 1595275-71-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SG3199
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SG3199 (SG-3199) 是抗体药物偶联物 (ADC) 负载 tesirine 的 PBD 二聚体弹头组件，对一组人类实体瘤和血液癌细胞系具有有效的细胞毒性，平均 GI50 为 151.5 pM。
产品描述

SG3199 (SG-3199) is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM; high-efficiently causes DNA interstrand cross-links in cancer cells; ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors.
体外实验

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体内实验

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同义词

SG-3199 | SG 3199
通路

Antibody Drug Conjugates (ADC)
靶点

ADC Cytotoxin
受体

ADC Cytotoxin
研究领域

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适应症

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CAS Number

1595275-71-0
分子量

584.673
分子式

C33H36N4O6
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 130 mg/mL (222.35 mM)
SMILES

O=C1C2=CC(OC)=C(OCCCCCOC3=C(OC)C=C4C(N=C[C@@](CC(C)=C5)([H])N5C4=O)=C3)C=C2N=C[C@@]6([H])N1C=C(C)C6
化学全称

7-methoxy-8-((5-(((S)-7-methoxy-2-methyl-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)pentyl)oxy)-2-methyl-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one