Sulpiride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sulpiride 是一种 D2 受体拮抗剂，一种苯甲酰胺类非典型抗精神病化合物。

Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression.

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Animal Model: Sprague-Dawley rats model Dosage:50 mg/kg Administration:Subcutaneous injection (s.c.); Single dose. Result:Caused dopamine concentrations in the dialysates to roughly double.Animal Model:6-hydroxydopamine (6-OHDA) male NMRI mouse model of Parkinson’s disease (PD) Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose Result:Decreased %OAT (open-arm time) but had no significant effect on %OAE (open-arm entries) and locomotor activity.Animal Model:Female nu/nu nude mouse models of breast cancer bearing MCF-7/Adr xenografts Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg Administration:Oral gavage (p.o.); Once daily for 18 days. In combination with DEX (1 and 10 mg/kg; p.o.; Once daily for 18 days) Result:When used in combination with DEX (1 mg/kg) at 50 m/kg, enhanced the tumor suppression rate (14.4%).When combined with DEX (8 mg/kg) at 25, 50, and 100 mg/kg, enhanced the tumor suppression rate by 30.2%, 27.55%, and 14.97%, respectively.

rac-Sulpiride | RD 1403 | (RS)-(±)-Sulpiride | (S)-Sulpiride

GPCR/G Protein

Dopamine Receptor

Dopamine

Neurological Disease

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15676-16-1

341.43

C15H23N3O4S

>98% (HPLC)

Soluble in DMSO

O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(N)=O)=CC=C2OC

N-((1-ethylpyrrolidin-2-yl)methyl)-2-methoxy-5-sulfamoylbenzamide

(-20℃)

With Ice Pack

≥ 2 years