Tolfenamic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

托芬那酸（TA）是一类非甾体抗炎药（NSAID）。

Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs).Tolfenamic acid is a NSAID. Tolfenamic acid treatment inhibited cell growth and induced apoptosis as measured by caspase activity and bioelectric impedance.(In Vitro):Tolfenamic Acid (GEA 6414) is a nonsteroidal antiinflammatory agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. Tolfenamic Acid (GEA 6414) (100 μM) inhibits >70% of cell viability of BE3, OE33, and SKGT5. Tolfenamic Acid (GEA 6414) also acts as a potent Sp protein inhibitor, decreases Sp1 and Sp4 and suppresses c-Met expression in esophageal cancer cells BE3 and SKGT5. Tolfenamic AcidTolfenamic Acid (GEA 6414) (50 μM) significantly affects gene expression in L3.6pl cells, and downregulates CENPF, KIF20A, LMNB1, MYB, SKP2, CCNE2, and DDIT3.(In Vivo):Tolfenamic Acid (GEA 6414) (50 mg/kg 3 times/wk, p.o.) inhibits tumor formation and tumor incidence in N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor model. Tolfenamic Acid (GEA 6414) also causes decreases in tumor multiplicity and tumor volume in rats treated with NMBA.

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Clotam

Chromatin/Epigenetic

COX

COX-2

Inflammation/Immunology

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13710-19-5

261.7

C14H12ClNO2

>98% (HPLC)

DMSO: 52 mg/mL (198.7 mM)

O=C(O)C1=CC=CC=C1NC2=CC=CC(Cl)=C2C

2-((3-chloro-2-methylphenyl)amino)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years