GSK2606414 ( GSK2606414 | GSK-2606414 | GSK PERK Inhibitor )

产品货号. M11350 CAS No. 1337531-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK2606414
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK2606414 是一种口服有效的选择性 PERK 抑制剂，IC50 为 0.4 nM。
产品描述

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.(In Vitro):GSK2606414 inhibits PERK activation in cells.(In Vivo):GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
体外实验

GSK2606414 inhibits PERK activation in cells.
体内实验

GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
同义词

GSK2606414 | GSK-2606414 | GSK PERK Inhibitor
通路

Apoptosis
靶点

PERK
受体

eIF-2AK1 (HRI)| eIF-2AK2 (PKR)| eIF-2AK3 (PERK)
研究领域

Cancer
适应症

——

CAS Number

1337531-36-8
分子量

451.44
分子式

C24H20F3N5O
纯度

>98% (HPLC)
溶解度

Ethanol: 19 mg/mL (42.08 mM); DMSO: 90 mg/mL (199.36 mM)
SMILES

FC(C1=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=CC=C1)(F)F
化学全称

1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone