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MPC-0767
CAS No. 1310540-32-9
MPC-0767 ( MPC 0767 | MPC0767 | MPC3100 mesylate hydrate )
产品货号. M11243 CAS No. 1310540-32-9
MPC-0767（MPC0767，MPC3100甲磺酸盐水合物）是MPC-3100的L-丙氨酸酯前药。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥9858 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MPC-0767
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MPC-0767（MPC0767，MPC3100甲磺酸盐水合物）是MPC-3100的L-丙氨酸酯前药。
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产品描述MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM; exhibits improved aqueous solubility, adequate chemical stability, and rapid bioconversion without the need for solubilizing excipients.
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体外实验——
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体内实验MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the Tmax, Cmax, AUC and F% are 1?(h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively.MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals.MPC-0767 is well tolerated when administered at 252?mg/kg po (equivalent to 200?mg/kg dose of?MPC-3100).
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同义词MPC 0767 | MPC0767 | MPC3100 mesylate hydrate
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP
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研究领域——
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适应症——
化学信息
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CAS Number1310540-32-9
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分子量663.559
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分子式C23H31BrN6O8S2
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纯度>98% (HPLC)
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溶解度——
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SMILESO.C[C@H](N)C(=O)O[C@@H](C)C(=O)N1CCC(CCn2c(Sc3cc4OCOc4cc3Br)nc5c(N)ncnc25)CC1.CS(=O)(=O)O
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化学全称(2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone mesylate hydrate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kim SH, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5254-7.
