Suramin sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苏拉明钠盐 (BAY-205, NF-060) 是一种抗锥虫化合物，还具有抗肿瘤活性；通过破坏其募集 Cdc34 的能力来抑制 CRL（Cullin-RING E3 泛素连接酶）活性。

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).Parasite Infection Approved.

Cell Proliferation Assay Cell Line:HO-8910 PM ovarian and Hela cervical cancer cells Concentration:50, 100, 200, 300, 400, 500 and 600 μg/mL.Incubation Time:For 24, 48, 72 and 96 hoursResult:Inhibited cells proliferation in a dose-dependent and time-dependent manner.Apoptosis Analysis Cell Line:HeLa cells Concentration:300 μg/mL .Incubation Time:For 48 hours Result:Induced cells apoptosis.Western Blot Analysis Cell Line:PA-SMCs cells. Concentration:1 mg/mL Incubation Time:For 1 hour Result:Significantly suppressed the phosphorylated ERK1/2.

Animal Model:Adult male Wistar rats (200-225 g )Dosage:10 mg/kg Administration:IV; twice weekly for 3 weeks Result:Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.

Suramin hexasodium salt | BAY-205 | NF-060

Proteasome/Ubiquitin

E3 Ubiquitin Ligase

TopoII

Infection

Parasite Infection

129-46-4

1429.171

C51H34N6Na6O23S6

>98% (HPLC)

H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming)

O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].

1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6)

(-20℃)

With Ice Pack

≥ 2 years