Azasetron hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Azasetron (Y-25130) hydrochloride，是一种苯甲酰胺的衍生物，是有效的、选择性的 5-HT3 受体拮抗剂。

Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.Azasetron inhibited the specific binding of [3H]quipazine to 5-HT3 receptors at the synaptic membranes of the rat cerebral cortex.(In Vivo):Azasetron could effectively penetrate through the skin and pass into the systemic circulation.

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Azasetron could effectively penetrate through the skin and pass into the systemic circulation. Animal Model:Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old).Dosage:0.5 mg/kg.Administration:I.V. administration via the abdominal vein.Result:The mean plasma concentration dropped to minimum at 36 h. Cmax = 44.88 ± 7.16 ng/mL) was achieved at the time point of 66.00 ± 22.98 h (Tmax).

Azasetron hydrochloride | Y 25130 | Y-25130 | Y25130.

Endocrinology/Hormones

5-HT Receptor

5-HT3

Neurological Disease

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123040-16-4

386.27

C17H20ClN3O3·HCl

>98% (HPLC)

Water: 3 mg/mL (7.76 mM)

c1(cc(C(N[C@@H]2CN3CCC2CC3)=O)c2c(c1)N(C)C(=O)CO2)Cl.Cl

2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-4-methyl-3-oxo-, monohydrochloride

(-20℃)

With Ice Pack

≥ 2 years