GLPG-0492

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种新型口服活性非甾体选择性雄激素受体调节剂 (SARM)，体外效力为 13 nM。

A novel, orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM; exhibits anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate in a classical model of orchidectomized rat; shows a potential treatment for Duchenne muscular dystrophy (DMD).Other Indication Phase 1 Clinical.

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GLPG0492

Endocrinology/Hormones

Androgen Receptor (AR)

Androgen Receptor (AR)

Other Indications

Other Disease

1215085-92-9

389.328

C19H14F3N3O3

>98% (HPLC)

10 mM in DMSO

N#CC1=CC=C(N(C(N(C)[C@]2(CO)C3=CC=CC=C3)=O)C2=O)C=C1C(F)(F)F

Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-

(-20℃)

With Ice Pack

≥ 2 years