BMS-794833

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS794833 是一种有效的 Met/VEGFR2 ATP 竞争性抑制剂，IC50 为 1.7 nM/15 nM。

BMS794833?is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM; also inhibits Ron, Axl and Flt-3 with IC50<3 nM; shows selectivity over a panel of >200 RTKs, non-RTKs and serine/threonine kinases; inhibits the cell growth in GTL-16 gastric carcinomas with an IC50 of 39 nM; active in multiple tumor models.Solid Tumors Phase 1 Clinical.

BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM.

BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days.

BMS794833

Angiogenesis

c-Met/HGFR

Met|VEGFR2

Cancer

Solid Tumors

1174046-72-0

468.84

C23H15ClF2N4O3

>98% (HPLC)

10 mM in DMSO

C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F

3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-

(-20℃)

With Ice Pack

≥ 2 years