JNJ-31020028

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JNJ-31020028是一种高亲和力的神经肽Y2受体选择性脑渗透拮抗剂（pIC50=8.07，人；pIC50=8.22大鼠）。

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.

JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC50 values of 8.07, 8.22 and 8.21, respectively.JNJ-31020028 (0.1 nM-10 μM; 1 hour) inhibits PYY-induced calcium response with a pKB value of 8.04.

JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals. Animal Model:Stressed and nonstressed male Sprague-Dawley ratsDosage:0, 3, 10 and 20 mg/kg Administration:Subcutaneous injection; 0-20 mg/kg once Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.

JNJ31020028 | JNJ 31020028 | JNJ-31020028

Others

Other Targets

Y2 receptor

Neurological Disease

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1094873-14-9

565.68

C34H36FN5O2

>98% (HPLC)

DMSO: 10 mM

O=C(NC1=CC=C(N2CCN(C(C3=CC=CC=C3)C(N(CC)CC)=O)CC2)C(F)=C1)C4=CC=CC=C4C5=CC=CN=C5

N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide

(-20℃)

With Ice Pack

≥ 2 years