LDN193189 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LDN193189 是一种有效的选择性 BMP I 型受体，可抑制 BMP4 诱导的 SMAD1/5/8 磷酸化，IC50 为 5 nM。

LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM); efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7; also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo.

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LDN 193189 hydrochloride | LDN-193189 hydrochloride

Angiogenesis

ALK

ALK2|ALK3

Cancer

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1062368-62-0

552.3261

C25H26Cl4N6

>98% (HPLC)

H2O: 20 mg/mL

[H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16

Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years